General Information

  • ID:  hor000317
  • Uniprot ID:  P41840
  • Protein name:  Leu-callatostatin
  • Gene name:  NA
  • Organism:  Calliphora vomitoria (Blue bottle fly) (Musca vomitoria)
  • Family:  Allatostatin family
  • Source:  Animal
  • Expression:  Brain, subesophageal ganglion, retrocerebral complex, thoracico-abdominal ganglion, peripheral neurosecretory system and intestine.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Calliphora (genus), Calliphorinae (subfamily), Calliphoridae (family), Oestroidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  RPYSFGL
  • Length:  7(2-8)
  • Propeptide:  DRPYSFGL
  • Signal peptide:  NA
  • Modification:  T7 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May act as a neurotransmitter or neuromodulator and play a role in the integration of information within the brain. May be involved in the control of visceral muscles due to its ability to behave as potent inhibitors of peristaltic movements. May also ful
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000317_AF2.pdbhor000317_ESM.pdb

Physical Information

Mass: 94615 Formula: C40H58N10O10
Absent amino acids: ACDEHIKMNQTVW Common amino acids: FGLPRSY
pI: 9.35 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -28.57 Boman Index: -962
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 55.71
Instability Index: 3608.57 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  8952000
  • Title:  Identification of the Dipteran Leu-callatostatin Peptide Family: The Pattern of Precursor Processing Revealed by Isolation Studies in Calliphora Vomitoria